In this article, we explore the associations of people’s valuations of universal healthcare with risk exposure and humanitarianism across diverse institutional contexts. We argue that both micro-level factors increase the valuations. Furthermore, interactions between material interests and humanitarians are expected. This work also hypothesizes that institutional contexts with employment-independent healthcare systems should modify the effect of risk exposure. Following a comparative framework, we test the expectations by using the International Social Survey Programme 2011 health module for 28 developed and developing countries. Results suggest opposite effects for the factors under analysis. While risk exposure decreases the willingness to pay taxes for the provision of universal healthcare, humanitarianism strongly fosters the valuation. Furthermore, we find statistical significant interactions between material interests and humanitarianism. Results also suggest substantive cross-level interactions between risk exposure and healthcare systems. Findings are robust to different modeling strategies that control for standard micro-level variables (income and egalitarianism), individual factors and observed and unobserved country characteristics. The article lays out implications of these findings.